Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane Amaia González-Magaña, Igor Tascon, Jon Altuna-Alvarez, María Queralt-Martín, Jake Colautti, Carmen Velázquez, Maialen Zabala, Jessica Rojas-Palomino, Marité Cárdenas, Antonio Alcaraz, John C. Whitney, Iban Ubarretxena-Belandia, David Albesa-Jove
Nature Communications, 14 Dec 2023 DOI: 10.1038/s41467-023-43585-5 Journal Paper B21-High Throughput SAXS Krios III-Titan Krios III at Diamond open access Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules Kyle W. Muir, Christopher Batters, Tom Dendooven, Jing Yang, Ziguo Zhang, Alister Burt, David Barford
Science, 382 Dec 2023 DOI: 10.1126/science.adj8736 The bacterial replication origin BUS promotes nucleobase capture Simone Pelliciari, Salomé Bodet-Lefèvre, Stepan Fenyk, Daniel Stevens, Charles Winterhalter, Frederic D. Schramm, Sara Pintar, Daniel R. Burnham, George Merces, Tomas T. Richardson, Yumiko Tashiro, Julia Hubbard, Hasan Yardimci, Aravindan Ilangovan, Heath Murray
Nature Communications, 14 Dec 2023 DOI: 10.1038/s41467-023-43823-w Journal Paper I24-Microfocus Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer’s disease and cerebral amyloid angiopathy Yang Yang, Alexey G. Murzin, Sew Peak-Chew, Catarina Franco, Holly J. Garringer, Kathy L. Newell, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Acta Neuropathologica Communications, 11 Dec 2023 DOI: 10.1186/s40478-023-01694-8 Structural basis of substrate progression through the bacterial chaperonin cycle Scott Gardner, Michele C. Darrow, Natalya Lukoyanova, Konstantinos Thalassinos, Helen R. Saibil
Proceedings Of The National Academy Of Sciences, 120 Dec 2023 DOI: 10.1073/pnas.2308933120 A closer look at how cells package DNA Diamond Light Source
Dec 2023 Science Highlight Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond
Molecular view of ER membrane remodeling by the Sec61/ TRAP translocon Sudeep Karki, Matti Javanainen, Shahid Rehan, Dale Tranter, Juho Kellosalo, Juha Huiskonen, Lotta Happonen, Ville Paavilainen
Embo Reports, 74 Nov 2023 DOI: 10.15252/embr.202357910 Investigating the protein subcomplexes from a conjugative Type IV Secretion System Himani Amin
Oct 2023 DOI: 10.25560/107342 Thesis Krios I-Titan Krios I at Diamond Structure of native chromatin fibres revealed by Cryo-ET in situ Zhen Hou, Frank Nightingale, Yanan Zhu, Craig Macgregor-Chatwin, Peijun Zhang
Nature Communications, 14 Oct 2023 DOI: 10.1038/s41467-023-42072-1 Journal Paper Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond open access An improved method for growing primary neurons on electron microscopy grids co-cultured with astrocytes Ishika Kumar, Anju Paudyal, Anna Kádková, Michelle Stewart, Jakob Balslev Sørensen, Julika Radecke
International Journal Of Molecular Sciences, 24 Oct 2023 DOI: 10.3390/ijms242015191 ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface Tao Ni, Luiza Mendonca, Yanan Zhu, Andrew Howe, Julika Radecke, Pranav M. Shah, Yuewen Sheng, Anna-Sophia Krebs, Helen M. E. Duyvesteyn, Elizabeth Allen, Teresa Lambe, Cameron Bisset, Alexandra Spencer, Susan Morris, David I. Stuart, Sarah Gilbert, Peijun Zhang
Iscience, Sept 2023 DOI: 10.1016/j.isci.2023.107882 Journal Paper Krios I-Titan Krios I at Diamond Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond open access CryoEM reveals that ribosomes in microsporidian spores are locked in a dimeric hibernating state Mathew Mclaren, Rebecca Conners, Michail N. Isupov, Patricia Gil-Díez, Lavinia Gambelli, Vicki A. M. Gold, Andreas Walter, Sean R. Connell, Bryony Williams, Bertram Daum
Nature Microbiology, 400 Sept 2023 DOI: 10.1038/s41564-023-01469-w Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly Tao Ni, Qiuyao Jiang, Pei Cing Ng, Juan Shen, Hao Dou, Yanan Zhu, Julika Radecke, Gregory F. Dykes, Fang Huang, Lu-Ning Liu, Peijun Zhang
Nature Communications, 14 Sept 2023 DOI: 10.1038/s41467-023-41211-y Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond open access Assembly mechanism of a Tad secretion system secretin-pilotin complex Matteo Tassinari, Marta Rudzite, Alain Filloux, Harry Low
Nature Communications, 14 Sept 2023 DOI: 10.1038/s41467-023-41200-1 Structure of the native chemotaxis core signaling unit from phage E-protein lysed E. coli cells C. Keith Cassidy, Zhuan Qin, Thomas Frosio, Khoosheh Gosink, Zhengyi Yang, Mark S. P. Sansom, Phillip J. Stansfeld, John S. Parkinson, Peijun Zhang
Mbio, Sept 2023 DOI: 10.1128/mbio.00793-23 Journal Paper Krios II-Titan Krios II at Diamond Krios III-Titan Krios III at Diamond open access A standard data format for 3DED/MicroED David G. Waterman, Noemi Frisina, C. David Owen, Graeme Winter, Pedro Nunes
Structure, 5 Aug 2023 DOI: 10.1016/j.str.2023.07.004 Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I Daniel Grba, Injae Chung, Hannah R. Bridges, Ahmed-Noor A. Agip, Judy Hirst
Science Advances, 9 Aug 2023 DOI: 10.1126/sciadv.adi1359 Journal Paper Krios I-Titan Krios I at Diamond Krios IV-Titan Krios IV at Diamond open access Molecular architecture and conservation of an immature human endogenous retrovirus Anna-Sophia Krebs, Hsuan-Fu Liu, Ye Zhou, Juan S. Rey, Lev Levintov, Juan Shen, Andrew Howe, Juan R. Perilla, Alberto Bartesaghi, Peijun Zhang
Nature Communications, 14 Aug 2023 DOI: 10.1038/s41467-023-40786-w Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4–NOT Eva Absmeier, Viswanathan Chandrasekaran, Francis J. O'Reilly, James A. W. Stowell, Juri Rappsilber, Lori Passmore
Nature Structural & Molecular Biology, 11 Aug 2023 DOI: 10.1038/s41594-023-01075-8 Using light and electron microscopy to understand the replication of aphthoviruses Pui Y. A. Lai
Aug 2023 Thesis B24-Cryo Soft X-ray Tomography Krios III-Titan Krios III at Diamond
Structure & function of bacterial transport machines in their cellular context Angela M. Kirykowicz
Aug 2023 Thesis Krios III-Titan Krios III at Diamond
Neutral sphingomyelinase 2 is required for HIV-1 maturation Abdul A. Waheed, Yanan Zhu, Eva Agostino, Lwar Naing, Yuta Hikichi, Ferri Soheilian, Seung-Wan Yoo, Yun Song, Peijun Zhang, Barbara S. Slusher, Norman J. Haughey, Eric O. Freed
Proceedings Of The National Academy Of Sciences, 120 Jul 2023 DOI: 10.1073/pnas.2219475120 Journal Paper Krios I-Titan Krios I at Diamond Krios IV-Titan Krios IV at Diamond Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism Smruti Ranjan Nayak, Deepthi Joseph, Georg Höfner, Archishman Dakua, Arunabh Athreya, Klaus T. Wanner, Baruch I. Kanner, Aravind Penmatsa
Nature Structural & Molecular Biology, 187 Jul 2023 DOI: 10.1038/s41594-023-01011-w Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere Tom Dendooven, Ziguo Zhang, Jing Yang, Stephen H. Mclaughlin, Johannes Schwab, Sjors H. W. Scheres, Stanislau Yatskevich, David Barford
Science Advances, 9 Jul 2023 DOI: 10.1126/sciadv.adg7480 Journal Paper Krios I-Titan Krios I at Diamond Krios III-Titan Krios III at Diamond open access Insights into a viral motor: the structure of the HK97 packaging termination assembly Dorothy E. D. P. Hawkins, Oliver W. Bayfield, Herman K. H. Fung, Daniel N. Grba, Alexis Huet, James f. Conway, Alfred A. Antson
Nucleic Acids Research, 51 Jul 2023 DOI: 10.1093/nar/gkad480 Cryo‐EM structure of antibacterial efflux transporter QacA from Staphylococcus aureus reveals a novel extracellular loop with allosteric role Puja Majumder, Shahbaz Ahmed, Pragya Ahuja, Arunabh Athreya, Rakesh Ranjan, Aravind Penmatsa
The Embo Journal, 301 Jul 2023 DOI: 10.15252/embj.2023113418 Histone divergence in trypanosomes results in unique alterations to nucleosome structure Gauri Deák, Hannah Wapenaar, Gorka Sandoval, Ruofan Chen, Mark r. D. Taylor, Hayden Burdett, James A. Watson, Maarten W. Tuijtel, Shaun Webb, Marcus D. Wilson
Nucleic Acids Research, 251 Jul 2023 DOI: 10.1093/nar/gkad577 Journal Paper B21-High Throughput SAXS Krios IV-Titan Krios IV at Diamond open access Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio Marston Bradshaw, John M. Squire, Edward Morris, Georgia Atkinson, Rebecca Richardson, Jon Lees, Massimo Caputo, Giulia M. Bigotti, Danielle M. Paul
Journal Of Muscle Research And Cell Motility, 7 Jul 2023 DOI: 10.1007/s10974-023-09653-5 Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound Seung-Wan Yoo, Abdul A. Waheed, Pragney Deme, Sehmus Tohumeken, Rana Rais, Matthew D. Smith, Catherine Demarino, Peter A. Calabresi, Fatah Kashanchi, Eric O. Freed, Barbara S. Slusher, Norman J. Haughey
Proceedings Of The National Academy Of Sciences, 120 Jul 2023 DOI: 10.1073/pnas.2219543120 Journal Paper Krios I-Titan Krios I at Diamond Krios IV-Titan Krios IV at Diamond open access Architecture of the ESCPE-1 membrane coat Carlos Lopez-Robles, Stefano Scaramuzza, Elsa Astorga-Simon, Morié Ishida, Chad D. Williamson, Soledad Banos-Mateos, David Gil-Carton, Miguel Romero-Durana, Ander Vidaurrazaga, Juan Fernandez-Recio, Adriana L. Rojas, Juan S. Bonifacino, Daniel Castaño-Díez, Aitor Hierro
Nature Structural & Molecular Biology, 23 June 2023 DOI: 10.1038/s41594-023-01014-7 CryoEM structure and Alphafold molecular modelling of a novel molluscan hemocyanin Gaia Pasqualetto, Andrew Mack, Emily Lewis, Ryan Cooper, Alistair Holland, Ufuk Borucu, Judith Mantell, Tom Davies, Miriam Weckener, Dan Clare, Tom Green, Pete Kille, Alex Muhlhozl, Mark T. Young
Plos One, 18 June 2023 DOI: 10.1371/journal.pone.0287294 Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation Markus Höpfler, Eva Absmeier, Sew-Yeu Peak-Chew, Evangelia Vartholomaiou, Lori A. Passmore, Ivana Gasic, Ramanujan S. Hegde
Molecular Cell, 10 June 2023 DOI: 10.1016/j.molcel.2023.05.020 Structural basis of ubiquitin‐independent PP1 complex disassembly by p97 Johannes Van Den Boom, Guendalina Marini, Hemmo Meyer, Helen Saibil
The Embo Journal, June 2023 DOI: 10.15252/embj.2022113110 The effect of inositol hexakisphosphate on HIV-1 particle production and infectivity can be modulated by mutations that affect the stability of the immature gag lattice Alex B. Kleinpeter, Yanan Zhu, Donna L. Mallery, Sherimay D. Ablan, Long Chen, Nathan Hardenbrook, Adolfo Saiardi, Leo C. James, Peijun Zhang, Eric O. Freed
Journal Of Molecular Biology, 435 June 2023 DOI: 10.1016/j.jmb.2023.168037 Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact α-carboxysome Sasha L. Evans, Monsour M. J. Al-Hazeem, Daniel Mann, Nicolas Smetacek, Andrew J. Beavil, Yaqi Sun, Taiyu Chen, Gregory F. Dykes, Lu-Ning Liu, Julien R. C. Bergeron
Structure, 31 June 2023 DOI: 10.1016/j.str.2023.03.008 Cryo-EM structure of the bacterial divisome core complex and antibiotic target FtsWIQBL Lisa Kashammer, Fusinita Van Den Ent, Magnus Jeffery, Nicolas L. Jean, Victoria L. Hale, Jan Lowe
Nature Microbiology, 8 June 2023 DOI: 10.1038/s41564-023-01368-0 Targeting a key COVID protein with antivirals Diamond Light Source
June 2023 Science Highlight Krios II-Titan Krios II at Diamond
Investigation of the milling characteristics of different focused-ion-beam sources assessed by three-dimensional electron diffraction from crystal lamellae James M. Parkhurst, Adam D. Crawshaw, C. Alistair Siebert, Maud Dumoux, C. David Owen, Pedro Nunes, David Waterman, Thomas Glen, David I. Stuart, James H. Naismith, Gwyndaf Evans
Iucrj, 10 May 2023 DOI: 10.1107/S2052252523001902 Cryo-electron microscopy of the f1 filamentous phage reveals insights into viral infection and assembly Rebecca Conners, Rayén Ignacia León-Quezada, Mathew Mclaren, Nicholas J. Bennett, Bertram Daum, Jasna Rakonjac, Vicki Gold
Nature Communications, 14 May 2023 DOI: 10.1038/s41467-023-37915-w Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex Mandy S. M. Wan, Reyhan Muhammad, Marios G. Koliopoulos, Theodoros I. Roumeliotis, Jyoti S. Choudhary, Claudio Alfieri
Nature Communications, 14 May 2023 DOI: 10.1038/s41467-023-38276-0 Structural atlas of a human gut crassvirus Oliver W. Bayfield, Andrey N. Shkoporov, Natalya Yutin, Ekaterina V. Khokhlova, Jake L. R. Smith, Dorothy E. D. P. Hawkins, Eugene V. Koonin, Colin Hill, Alfred A. Antson
Nature, 25 May 2023 DOI: 10.1038/s41586-023-06019-2 Signal peptide mimicry primes Sec61 for client-selective inhibition Shahid Rehan, Dale Tranter, Phillip P. Sharp, Gregory B. Craven, Eric Lowe, Janet L. Anderl, Tony Muchamuel, Vahid Abrishami, Suvi Kuivanen, Nicole A. Wenzell, Andy Jennings, Chakrapani Kalyanaraman, Tomas Strandin, Matti Javanainen, Olli Vapalahti, Matthew P. Jacobson, Dustin Mcminn, Christopher J. Kirk, Juha T. Huiskonen, Jack Taunton, Ville O. Paavilainen
Nature Chemical Biology, 1808 May 2023 DOI: 10.1038/s41589-023-01326-1 The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin Charles Winterhalter, Simone Pelliciari, Daniel Stevens, Stepan Fenyk, Elie Marchand, Nora B. Cronin, Panos Soultanas, Tiago R. D. Costa, Aravindan Ilangovan, Heath Murray
Nucleic Acids Research, 51 May 2023 DOI: 10.1093/nar/gkad277 Harnessing the power of cryo electron microscopy to visualise a full-length kinesin KIFC1 (HSET) Varun Ramaswamy
May 2023 Thesis B21-High Throughput SAXS Krios I-Titan Krios I at Diamond
mRNA recognition and packaging by the human transcription–export complex Belén Pacheco-Fiallos, Matthias K. Vorleander, Daria Riabov-Bassat, Laura Fin, Francis J. O'Reilly, Farja I. Ayala, Ulla Schellhaas, Juri Rappsilber, Clemens Plaschka
Nature, 8 Apr 2023 DOI: 10.1038/s41586-023-05904-0 Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease Andre Schutzer Godoy, Aline Minalli Nakamura, Alice Douangamath, Yun Song, Gabriela Dias Noske, Victor Oliveira Gawriljuk , Rafaela Sachetto Fernandes, Humberto D'Muniz Pereira, Ketllyn irene Zagato Oliveira, Daren Fearon, Alexandre Dias, Tobias Krojer, Michael Fairhead, Alisa Powell, Louise Dunnett, Jose Brandao-Neto, Rachael Skyner, Rod Chalk, Dávid Bajusz, Miklós Bege, Anikó Borbás, György Miklós Keserű, Frank Von Delft, Glaucius Oliva
Nucleic Acids Research, 579 Apr 2023 DOI: 10.1093/nar/gkad314 Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) Krios II-Titan Krios II at Diamond open access Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site Alan R. F. Godwin, Rana Dajani, Xinyang Zhang, Jennifer Thomson, David F. Holmes, Christin S. Adamo, Gerhard Sengle, Michael J. Sherratt, Alan M. Roseman, Clair Baldock
Nature Structural & Molecular Biology, 84 Apr 2023 DOI: 10.1038/s41594-023-00950-8 IS21 family transposase cleaved donor complex traps two right-handed superhelical crossings Mercedes Spínola-Amilibia, Lidia Araujo-Bazan, Alvaro De La Gandara, James M. Berger, Ernesto Arias-Palomo
Nature Communications, 14 Apr 2023 DOI: 10.1038/s41467-023-38071-x Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments Xinrui Huang, Iratxe Torre, Michele Chiappi, Zhan Yin, Anupama Vydyanath, Shuangyi Cao, Oliver Raschdorf, Morgan Beeby, Bonnie Quigley, Pieter P. De Tombe, Jun Liu, Edward P. Morris, Pradeep K. Luther
Journal Of Muscle Research And Cell Motility, 189 Apr 2023 DOI: 10.1007/s10974-023-09647-3 The lipid linked oligosaccharide polymerase Wzy and its regulating co-polymerase, Wzz, from enterobacterial common antigen biosynthesis form a complex Miriam Weckener, Laura S. Woodward, Bradley R. Clarke, Huanting Liu, Philip N. Ward, Audrey Le Bas, David Bhella, Chris Whitfield, James H. Naismith
Open Biology, 13 Mar 2023 DOI: 10.1098/rsob.220373 Characterization of the rotavirus assembly pathway in situ using cryoelectron tomography Pranav N. M. Shah, James B. Gilchrist, Björn O. Forsberg, Alister Burt, Andrew Howe, Shyamal Mosalaganti, William Wan, Julika Radecke, Yuriy Chaban, Geoff Sutton, David I. Stuart, Mark Boyce
Cell Host & Microbe, 190 Mar 2023 DOI: 10.1016/j.chom.2023.03.004 Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics James Wagstaff, Vicente J. Planelles-Herrero, Grigory Sharov, Aisha Alnami, Frank Kozielski, Emmanuel Derivery, Jan Lowe
Science Advances, 9 Mar 2023 DOI: 10.1126/sciadv.adf3021 An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition Gabriela Dias Noske, Yun Song, Rafaela Sachetto Fernandes, Rod Chalk, Haitem Elmassoudi, Lizbe Koekemoer, C. David Owen, Tarick J. El-Baba, Carol V. Robinson, Glaucius Oliva, Andre Schutzer Godoy
Nature Communications, 14 Mar 2023 DOI: 10.1038/s41467-023-37035-5 A review of the approaches used to solve sub-100 kDa membrane proteins by cryo-electron microscopy Peter J. Harrison, Tereza Vecerkova, Daniel K. Clare, Andrew Quigley
Journal Of Structural Biology, 7 Mar 2023 DOI: 10.1016/j.jsb.2023.107959 Cryo-EM structure of the four-subunit Rhodobacter sphaeroides cytochrome bc1 complex in styrene maleic acid nanodiscs David J. K. Swainsbury, Frederick Hawkings, Elizabeth C. Martin, Sabina Musial, Jack H. Salisbury, Philip J. Jackson, David A. Farmer, Matthew P. Johnson, C. Alistair Siebert, Andrew Hitchcock, C. Neil Hunter
Proceedings Of The National Academy Of Sciences, 120 Mar 2023 DOI: 10.1073/pnas.2217922120 Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration Phong Quoc Nguyen, Sonia Huecas, Amna Asif-Laidin, Adrián Plaza-Pegueroles, Beatrice Capuzzi, Noé Palmic, Christine Conesa, Joël Acker, Juan Reguera, Pascale Lesage, Carlos Fernandez-Tornero
Nature Communications, 14 Mar 2023 DOI: 10.1038/s41467-023-37109-4 Mechanism of receptor assembly via the pleiotropic adipokine Leptin Alexandra Tsirigotaki, Ann Dansercoer, Koen H. G. Verschueren, Iva Marković, Christoph Pollmann, Maximillian Hafer, Jan Felix, Catherine Birck, Wouter Van Putte, Dominiek Catteeuw, Jan Tavernier, J. Fernando Bazan, Jacob Piehler, Savvas N. Savvides, Kenneth Verstraete
Nature Structural & Molecular Biology, 387 Mar 2023 DOI: 10.1038/s41594-023-00941-9 Ot2Rec: A semi-automatic, extensible, multi-software tomographic reconstruction workflow Neville B.-Y. Yee, Elaine M. L. Ho, Win Tun, Jake L. R. Smith, Maud Dumoux, Michael Grange, Michele C. Darrow, Mark Basham
Biological Imaging, 3 Mar 2023 DOI: 10.1017/S2633903X23000107 Structure of the Saccharolobus solfataricus type III-D CRISPR effector Giuseppe Cannone, Dmytro Kompaniiets, Shirley Graham, Malcolm F. White, Laura Spagnolo
Current Research In Structural Biology, 9 Feb 2023 DOI: 10.1016/j.crstbi.2023.100098 Structural remodelling of the carbon–phosphorus lyase machinery by a dual ABC ATPase Søren K. Amstrup, Sui Ching Ong, Nicholas Sofos, Jesper L. Karlsen, Ragnhild B. Skjerning, Thomas Boesen, Jan J. Enghild, Bjarne Hove-Jensen, Ditlev E. Brodersen
Nature Communications, 14 Feb 2023 DOI: 10.1038/s41467-023-36604-y Structural basis for membrane attack complex inhibition by CD59 Emma C. Couves, Scott Gardner, Tomas B. Voisin, Jasmine K. Bickel, Phillip J. Stansfeld, Edward W. Tate, Doryen Bubeck
Nature Communications, 14 Feb 2023 DOI: 10.1038/s41467-023-36441-z Journal Paper Krios II-Titan Krios II at Diamond Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond open access New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy Yang Yang, Holly J. Garringer, Yang Shi, Sofia Lovestam, Sew Peak-Chew, Xianjun Zhang, Abhay Kotecha, Mehtap Bacioglu, Atsuo Koto, Masaki Takao, Maria Grazia Spillantini, Bernardino Ghetti, Ruben Vidal, Alexey G. Murzin, Sjors H. W. Scheres, Michel Goedert
Acta Neuropathologica, 26 Feb 2023 DOI: 10.1007/s00401-023-02550-8 Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains Yang Yang, Wenjuan Zhang, Alexey G. Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lovestam, Sew Y. Peak-Chew, Takashi Saito, Takaomi C. Saido, Jennifer Macdonald, Isabelle Lavenir, Bernardino Ghetti, Caroline Graff, Amit Kumar, Agneta Nordberg, Michel Goedert, Sjors H. W. Scheres
Acta Neuropathologica, 65 Jan 2023 DOI: 10.1007/s00401-022-02533-1 Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides Hannah Bridges, James N. Blaza, Zhan Yin, Injae Chung, Michael N. Pollak, Judy Hirst
Science, 379 Jan 2023 DOI: 10.1126/science.ade3332 Journal Paper Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond A molecular network of conserved factors keeps ribosomes dormant in the egg Friederike Leesch, Laura Lorenzo-Orts, Carina Pribitzer, Irina Grishkovskaya, Josef Roehsner, Anastasia Chugunova, Manuel Matzinger, Elisabeth Roitinger, Katarina Belačić, Susanne Kandolf, Tzi-Yang Lin, Karl Mechtler, Anton Meinhart, David Haselbach, Andrea Pauli
Nature, 40 Jan 2023 DOI: 10.1038/s41586-022-05623-y