Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 Å resolution Nopnithi Thonghin, Richard F. Collins, Alessandro Barbieri, Talha Shafi, Alistair Siebert, Robert C. Ford
Bmc Structural Biology, 18 Dec 2018 DOI: 10.1186/s12900-018-0098-z CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers Anais Menny, Marina Serna, Courtney N. Boyd, Scott Gardner, Agnel Praveen Joseph, B. Paul Morgan, Maya Topf, Nicholas J. Brooks, Doryen Bubeck
Nature Communications, 9 Dec 2018 DOI: 10.1038/s41467-018-07653-5 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1 Andrew M. Hartley, Natalya Lukoyanova, Yunyi Zhang, Alfredo Cabrera-Orefice, Susanne Arnold, Brigitte Meunier, Nikos Pinotsis, Amandine Marechal
Nature Structural & Molecular Biology, 26 Dec 2018 DOI: 10.1038/s41594-018-0172-z Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri Germán G. Sgro, Tiago R. D. Costa, William Cenens, Diorge P. Souza, Alexandre Cassago, Luciana Coutinho De Oliveira, Roberto K. Salinas, Rodrigo V. Portugal, Chuck S. Farah, Gabriel Waksman
Nature Microbiology, 3 Dec 2018 DOI: 10.1038/s41564-018-0262-z Secrets of the deadly white-tail virus revealed Diamond Light Source
Dec 2018 Science Highlight Krios I-Titan Krios I at Diamond
Cryo-EM structures of MDA5-dsRNA filaments at different stages of ATP hydrolysis Qin Yu, Kun Qu, Yorgo Modis
Molecular Cell, Nov 2018 DOI: 10.1016/j.molcel.2018.10.012 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G. Murzin, Ruben Vidal, Holly J. Garringer, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert
Acta Neuropathologica, 136 Nov 2018 DOI: 10.1007/s00401-018-1914-z Structure and dynamics of the yeast SWR1-nucleosome complex Oliver Willhoft, Mohamed Ghoneim, Chia-Liang Lin, Eugene Y. D. Chua, Martin Wilkinson, Yuriy Chaban, Rafael Ayala, Elizabeth A. Mccormack, Lorraine Ocloo, David S. Rueda, Dale B. Wigley
Science, 362 Oct 2018 DOI: 10.1126/science.aat7716 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Using Scipion for stream image processing at Cryo-EM facilities J. Gómez-Blanco, J. M. De La Rosa-Trevín, R. Marabini, L. Del Cano, A. Jiménez, M. Martínez, R. Melero, T. Majtner, D. Maluenda, J. Mota, Y. Rancel, E. Ramírez-Aportela, J. I. Vilas, M. Carroni, S. Fleischmann, E. Lindahl, A. W. Ashton, M. Basham, D. K. Clare, K. Savage, C. A. Siebert, G. G. Sharov, C. O. S. Sorzano, P. Conesa, J. M. Carazo
Journal Of Structural Biology, Oct 2018 DOI: 10.1016/j.jsb.2018.10.001 Structure of the Macrobrachium rosenbergii nodavirus: A new genus within the Nodaviridae? Kok Lian Ho, Mads Gabrielsen, Poay Ling Beh, Chare Li Kueh, Qiu Xian Thong, James Streetley, Wen Siang Tan, David Bhella
Plos Biology, 16 Oct 2018 DOI: 10.1371/journal.pbio.3000038 Structure of mutant hepatitis B core protein capsids with premature secretion phenotype Bettina Böttcher, Michael Nassal
Journal Of Molecular Biology, Oct 2018 DOI: 10.1016/j.jmb.2018.10.018 Chimeric O1K foot-and-mouth disease virus with SAT2 outer capsid as an FMD vaccine candidate Abhay Kotecha, Eva Perez-Martin, Yongjie Harvey, Fuquan Zhang, Serban L. Ilca, Elizabeth E. Fry, Ben Jackson, Francois Maree, Katherine Scott, Corey W. Hecksel, Michiel M. Harmsen, Valérie Mioulet, Britta Wood, Nick Juleff, David I. Stuart, Bryan Charleston, Julian Seago
Scientific Reports, 8 Sept 2018 DOI: 10.1038/s41598-018-31856-x Structural cycle of the Thermus thermophilus PilF ATPase: the powering of type IVa pilus assembly Richard Collins, Vijaykumar Karuppiah, C. Alistair Siebert, Rana Dajani, Angela Thistlethwaite, Jeremy P. Derrick
Scientific Reports, 8 Sept 2018 DOI: 10.1038/s41598-018-32218-3 Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access State-of-the-art imaging and image processing offer new insights into Herpes simplex virus Diamond Light Source
Sept 2018 Science Highlight Krios IV-Titan Krios IV at Diamond
Structures of the fungal dynamin-related protein Vps1 reveal a unique, open helical architecture Natalia V. Varlakhanova, Frances J. D. Alvarez, Tyler M. Brady, Bryan A. Tornabene, Christopher J. Hosford, Joshua S. Chappie, Peijun Zhang, Marijn G. J. Ford
The Journal Of Cell Biology, 14 Aug 2018 DOI: 10.1083/jcb.201712021 Structural basis for membrane tethering by a bacterial dynamin-like pair Jiwei Liu, Jeffrey K. Noel, Harry H. Low
Nature Communications, 9 Aug 2018 DOI: 10.1038/s41467-018-05523-8 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access Structural basis of RNA polymerase I stalling at UV light-induced DNA damage Marta Sanz-Murillo, Jun Xu, Georgiy A. Belogurov, Olga Calvo, David Gil-Carton, María Moreno-Morcillo, Dong Wang, Carlos Fernández-Tornero
Proceedings Of The National Academy Of Sciences, 93 Aug 2018 DOI: 10.1073/pnas.1802626115 Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome Ramasubramanian Sundaramoorthy, Amanda L. Hughes, Hassane El-Mkami, David G. Norman, Helder Ferreira, Tom Owen-Hughes
Elife, 7 Aug 2018 DOI: 10.7554/eLife.35720 Structure of the herpes simplex virus portal-vertex Marion Mcelwee, Swetha Vijayakrishnan, Frazer Rixon, David Bhella
Plos Biology, 16 Jul 2018 DOI: 10.1371/journal.pbio.2006191 Insights into centromere DNA bending revealed by the cryo-EM structure of the core centromere binding factor 3 with Ndc10 Wenjuan Zhang, Natalya Lukoyanova, Shomon Miah, Jonathan Lucas, Cara K. Vaughan
Cell Reports, 24 Jul 2018 DOI: 10.1016/j.celrep.2018.06.068 Structures of bacterial RNA polymerase complexes reveal the mechanism of DNA loading and transcription initiation Robert Glyde, Fuzhou Ye, Milija Jovanovic, Ioly Kotta-Loizou, Martin Buck, Xiaodong Zhang
Molecular Cell, 70 June 2018 DOI: 10.1016/j.molcel.2018.05.021 Flexible helper of protein folding Diamond Light Source
June 2018 Science Highlight Krios I-Titan Krios I at Diamond
Structure and regulation of the human INO80–nucleosome complex Rafael Ayala, Oliver Willhoft, Ricardo J. Aramayo, Martin Wilkinson, Elizabeth A. Mccormack, Lorraine Ocloo, Dale B. Wigley, Xiaodong Zhang
Nature, 556 Apr 2018 DOI: 10.1038/s41586-018-0021-6 Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor Annemarie Perez Boerema, Shintaro Aibara, Bijoya Paul, Victor Tobiasson, Dari Kimanius, Björn O. Forsberg, Karin Wallden, Erik Lindahl, Alexey Amunts
Nature Plants, 4 Apr 2018 DOI: 10.1038/s41477-018-0129-6 RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex Fabrizio Martino, Mohinder Pal, Hugo Muñoz-Hernández, Carlos F. Rodríguez, Rafael Núñez-Ramírez, David Gil-Carton, Gianluca Degliesposti, J. Mark Skehel, Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, Oscar Llorca
Nature Communications, 9 Apr 2018 DOI: 10.1038/s41467-018-03942-1 Cryo-EM structure of the Blastochloris viridis LH1–RC complex at 2.9 Å Pu Qian, C. Alistair Siebert, Peiyi Wang, Daniel P. Canniffe, C. Neil Hunter
Nature, 103 Apr 2018 DOI: 10.1038/s41586-018-0014-5 Hexameric and pentameric complexes of the ExbBD energizer in the Ton system Saori Maki-Yonekura, Rei Matsuoka, Hirofumi Shimizu, Maiko Tanaka, Fumie Iwabuki, Koji Yonekura
Elife, Apr 2018 DOI: 10.7554/eLife.35419 Red light photosynthesis Diamond Light Source
Apr 2018 Science Highlight Krios I-Titan Krios I at Diamond
A dance of enzymes Diamond Light Source
Feb 2018 Science Highlight Krios II-Titan Krios II at Diamond
Combined 1H-detected solid-state NMR spectroscopy and electron cryotomography to study membrane proteins across resolutions in native environments Lindsay A. Baker, Tessa Sinnige, Pascale Schellenberger, Jeanine De Keyzer, C. Alistair Siebert, Arnold J. M. Driessen, Marc Baldus, Kay Grunewald
Structure, 26 Jan 2018 DOI: 10.1016/j.str.2017.11.011 Journal Paper Krios I-Titan Krios I at Diamond M01-Polara at OPIC (Oxford) open access Structure of the deactive state of mammalian respiratory Complex I James N. Blaza, Kutti R. Vinothkumar, Judy Hirst
Structure, Jan 2018 DOI: 10.1016/j.str.2017.12.014 Structural basis of RNA polymerase III transcription initiation Guillermo Abascal-Palacios, Ewan Phillip Ramsay, Fabienne Beuron, Edward Morris, Alessandro Vannini
Nature, 553 Jan 2018 DOI: 10.1038/nature25441