Structure, mechanism, and inhibition of Hedgehog acyltransferase Claire E. Coupland, Sebastian A. Andrei, T. Bertie Ansell, Loic Carrique, Pramod Kumar, Lea Sefer, Rebekka A. Schwab, Eamon F. X. Byrne, Els Pardon, Jan Steyaert, Anthony I. Magee, Thomas Lanyon-Hogg, Mark S. P. Sansom, Edward W. Tate, Christian Siebold
Molecular Cell, 179 Dec 2021 DOI: 10.1016/j.molcel.2021.11.018 Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes Guillermo Abascal-Palacios, Laura Jochem, Carlos Pla-Prats, Fabienne Beuron, Alessandro Vannini
Nature Communications, 12 Dec 2021 DOI: 10.1038/s41467-021-27338-w Journal Paper Krios I-Titan Krios I at Diamond Krios IV-Titan Krios IV at Diamond open access Architecture of the outer-membrane core complex from a conjugative type IV secretion system Himani Amin, Aravindan Ilangovan, Tiago R. D. Costa
Nature Communications, 12 Dec 2021 DOI: 10.1038/s41467-021-27178-8 Helical ordering of envelope‐associated proteins and glycoproteins in respiratory syncytial virus Michaela J Conley, Judith M. Short, Andrew Burns, James Streetley, Joshua Hutchings, Saskia E. Bakker, B. Joanne Power, Hussain Jaffery, Joanne Haney, Giulia Zanetti, Pablo R. Murcia, Murray Stewart, Rachel Fearns, Swetha Vijayakrishnan, David Bhella
The Embo Journal, 12 Dec 2021 DOI: 10.15252/embj.2021109728 CryoEM of RUVBL1–RUVBL2–ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8 Marina Serna, Ana González-Corpas, Sofía Cabezudo, Andres Lopez-Perrote, Gianluca Degliesposti, Eduardo Zarzuela, J. mark Skehel, Javier Muñoz, Oscar Llorca
Nucleic Acids Research, 493 Dec 2021 DOI: 10.1093/nar/gkab1267 Structural basis for substrate specificity of heteromeric transporters of neutral amino acids Carlos F. Rodriguez, Paloma Escudero-Bravo, Lucía Díaz, Paola Bartoccioni, Carmen Garcia-Martin, Joan G. Gilabert, Jasminka Boskovic, Víctor Guallar, Ekaitz Errasti-Murugarren, Oscar Llorca, Manuel Palacín
Proceedings Of The National Academy Of Sciences, 118 Dec 2021 DOI: 10.1073/pnas.2113573118 Cryo-EM structures of two bacteriophage portal proteins provide insights for antimicrobial phage engineering Abid Javed, Hugo Villanueva, Shadikejiang Shataer, Sara Vasciaveo, Renos Savva, Elena V. Orlova
Viruses, 13 Dec 2021 DOI: 10.3390/v13122532 Understanding the mechanisms behind COVID and how to combat it Diamond Light Source
Dec 2021 Science Highlight Krios II-Titan Krios II at Diamond
Structures of class I and class II transcription complexes reveal the molecular basis of RamA-dependent transcription activation Min Hao, Fuzhou Ye, Milija Jovanovic, Ioly Kotta‐loizou, Qingqing Xu, Xiaohua Qin, Martin Buck, Xiaodong Zhang, Minggui Wang
Advanced Science, 141 Nov 2021 DOI: 10.1002/advs.202103669 Journal Paper Krios I-Titan Krios I at Diamond Krios IV-Titan Krios IV at Diamond open access CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage Rebecca Conners, Mathew Mclaren, Urszula Łapińska, Kelly Sanders, M. Rhia L. Stone, Mark A. T. Blaskovich, Stefano Pagliara, Bertram Daum, Jasna Rakonjac, Vicki A. M. Gold
Nature Communications, 12 Nov 2021 DOI: 10.1038/s41467-021-26610-3 MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA Qin Yu, Alba Herrero Del Valle, Rahul Singh, Yorgo Modis
Nature Communications, 12 Nov 2021 DOI: 10.1038/s41467-021-27062-5 Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis Martin G. Montgomery, Jessica Petri, Tobias E. Spikes, John E. Walker
Proceedings Of The National Academy Of Sciences, 118 Nov 2021 DOI: 10.1073/pnas.2111899118 Journal Paper Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond open access The proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila Kevin Mace, Amit Meir, Natalya Lukoyanova, Luying Liu, David Chetrit, Manuela K. Hospenthal, Craig R. Roy, Gabriel Waksman
Molecular Microbiology, Nov 2021 DOI: 10.1111/mmi.14847 Structure of native HIV-1 cores and their interactions with IP6 and CypA Tao Ni, Yanan Zhu, Zhengyi Yang, Chaoyi Xu, Yuriy Chaban, Tanya Nesterova, Jiying Ning, Till Böcking, Michael W. Parker, Christina Monnie, Jinwoo Ahn, Juan R. Perilla, Peijun Zhang
Science Advances, 7 Nov 2021 DOI: 10.1126/sciadv.abj5715 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond open access Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT Richard W. Meek, James N. Blaza, Jil A. Busmann, Matthew G. Alteen, David J. Vocadlo, Gideon Davies
Nature Communications, 12 Nov 2021 DOI: 10.1038/s41467-021-26796-6 Using toxins to study HIV Diamond Light Source
Nov 2021 Science Highlight Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond
Structural basis of soluble membrane attack complex packaging for clearance Anais Menny, Marie V. Lukassen, Emma C. Couves, Vojtech Franc, Albert J. R. Heck, Doryen Bubeck
Nature Communications, 12 Oct 2021 DOI: 10.1038/s41467-021-26366-w Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access AKIRIN2 controls the nuclear import of proteasomes in vertebrates Melanie De Almeida, Matthias Hinterndorfer, Hanna Brunner, Irina Grishkovskaya, Kashish Singh, Alexander Schleiffer, Julian Jude, Sumit Deswal, Robert Kalis, Milica Vunjak, Thomas Lendl, Richard Imre, Elisabeth Roitinger, Tobias Neumann, Susanne Kandolf, Michael Schutzbier, Karl Mechtler, Gijs A. Versteeg, David Haselbach, Johannes Zuber
Nature, 98 Oct 2021 DOI: 10.1038/s41586-021-04035-8 A conserved mechanism for regulating replisome disassembly in eukaryotes Michael Jenkyn-Bedford, Morgan L. Jones, Yasemin Baris, Karim P. M. Labib, Giuseppe Cannone, Joseph T. P. Yeeles, Tom D. Deegan
Nature, 600 Oct 2021 DOI: 10.1038/s41586-021-04145-3 Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides Dmitry Ghilarov, Satomi Inaba-Inoue, Piotr Stepien, Feng Qu, Elizabeth Michalczyk, Zuzanna Pakosz, Norimichi Nomura, Satoshi Ogasawara, Graham Charles Walker, Sylvie Rebuffat, So Iwata, Jonathan Gardiner Heddle, Konstantinos Beis
Science Advances, 7 Sept 2021 DOI: 10.1126/sciadv.abj5363 Two-dimensional electronic spectroscopy of a minimal photosystem I complex reveals the rate of primary charge separation Parveen Akhtar, Ido Caspy, Paweł J. Nowakowski, Tirupathi Malavath, Nathan Nelson, Howe-Siang Tan, Petar H. Lambrev
Journal Of The American Chemical Society, Sept 2021 DOI: 10.1021/jacs.1c05010 A CDK-regulated chromatin segregase promoting chromosome replication Erika Chacin, Priyanka Bansal, Karl-Uwe Reusswig, Luis M. Diaz-Santin, Pedro Ortega, Petra Vizjak, Belen Gomez-Gonzalez, Felix Müller-Planitz, Andrés Aguilera, Boris Pfander, Alan C. M. Cheung, Christoph F. Kurat
Nature Communications, 12 Sept 2021 DOI: 10.1038/s41467-021-25424-7 CryoEM structure of the super-constricted two-start dynamin 1 filament Jiwei Liu, Frances Joan D. Alvarez, Daniel K. Clare, Jeffrey K. Noel, Peijun Zhang
Nature Communications, 12 Sept 2021 DOI: 10.1038/s41467-021-25741-x Structural basis of RNA polymerase inhibition by viral and host factors Simona Pilotto, Thomas Fouqueau, Natalya Lukoyanova, Carol Sheppard, Soizick Lucas-Staat, Luis Miguel Diaz-Santin, Dorota Matelska, David Prangishvili, Alan C. M. Cheung, Finn Werner
Nature Communications, 12 Sept 2021 DOI: 10.1038/s41467-021-25666-5 Journal Paper Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond open access Unwinding of a DNA replication fork by a hexameric viral helicase Abid Javed, Balazs Major, Jonathan A. Stead, Cyril M. Sanders, Elena V. Orlova
Nature Communications, 12 Sept 2021 DOI: 10.1038/s41467-021-25843-6 The structure of the bacterial DNA segregation ATPase filament reveals the conformational plasticity of ParA upon DNA binding Alexandra V. Parker, Daniel Mann, Svetomir B. Tzokov, Ling C. Hwang, Julien R. C. Bergeron
Nature Communications, 12 Aug 2021 DOI: 10.1038/s41467-021-25429-2 Journal Paper I03-Macromolecular Crystallography Krios II-Titan Krios II at Diamond open access Cryo-electron microscopy of HPV16 pseudovirions reveal changes in capsid conformation upon furin cleavage Melissa Lauren Marx
Aug 2021 Thesis Krios I-Titan Krios I at Diamond
Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses Sofia Banchenko, Ferdinand Krupp, Christine Gotthold, Jörg Bürger, Andrea Graziadei, Francis O'Reilly, Ludwig Sinn, Olga Ruda, Juri Rappsilber, Christian M. T. Spahn, Thorsten Mielke, Ian A. Taylor, David Schwefel
Plos Pathogens, 17 Aug 2021 DOI: 10.1371/journal.ppat.1009775 Journal Paper I04-Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access Assisted assembly of bacteriophage T7 core components for genome translocation across the bacterial envelope Mar Pérez-Ruiz, Mar Pulido-Cid, Juan Román Luque-Ortega, José Maria Valpuesta, Ana Cuervo, José L. Carrascosa
Proceedings Of The National Academy Of Sciences, 118 Aug 2021 DOI: 10.1073/pnas.2026719118 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond The molecular basis of regulation of bacterial capsule assembly by Wzc Yun Yang, Jiwei Liu, Bradley R. Clarke, Laura Seidel, Jani R. Bolla, Philip N. Ward, Peijun Zhang, Carol V. Robinson, Chris Whitfield, James Naismith
Nature Communications, 12 Jul 2021 DOI: 10.1038/s41467-021-24652-1 CryoEM structure of the Nipah virus nucleocapsid assembly De-Sheng Ker, Huw T. Jenkins, Sandra J. Greive, Alfred A. Antson
Plos Pathogens, 17 Jul 2021 DOI: 10.1371/journal.ppat.1009740 Structural basis of human separase regulation by securin and CDK1–cyclin B1 Jun Yu, Pierre Raia, Chloe M. Ghent, Tobias Raisch, Yashar Sadian, Simone Cavadini, Pramod M. Sabale, David Barford, Stefan Raunser, David O. Morgan, Andreas Boland
Nature, 112 Jul 2021 DOI: 10.1038/s41586-021-03764-0 Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone Mohinder Pal, Hugo Munoz-Hernandez, Dennis Bjorklund, Lihong Zhou, Gianluca Degliesposti, J. Mark Skehel, Emma L. Hesketh, Rebecca F. Thompson, Laurence H. Pearl, Oscar Llorca, Chrisostomos Prodromou
Cell Reports, 36 Jul 2021 DOI: 10.1016/j.celrep.2021.109317 Structural basis for a neutralizing antibody response elicited by a recombinant hantaan virus Gn immunogen Ilona Rissanen, Stefanie A. Krumm, Robert Stass, Annalis Whitaker, James E. Voss, Emily A. Bruce, Sylvia Rothenberger, Stefan Kunz, Dennis R. Burton, Juha T. Huiskonen, Jason W. Botten, Thomas A. Bowden, Katie J. Doores
Mbio, 146 Jul 2021 DOI: 10.1128/mBio.02531-20 Journal Paper I03-Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress Luiza Mendonca, Andrew Howe, James B. Gilchrist, Yuewen Sheng, Dapeng Sun, Michael L. Knight, Laura C. Zanetti-Domingues, Benji Bateman, Anna-Sophia Krebs, Long Chen, Julika Radecke, Vivian D. Li, Tao Ni, Ilias Kounatidis, Mohamed A. Koronfel, Marta Szynkiewicz, Maria Harkiolaki, Marisa Martin-Fernandez, William James, Peijun Zhang
Nature Communications, 12 Jul 2021 DOI: 10.1038/s41467-021-24887-y Journal Paper B24-Cryo Soft X-ray Tomography Krios II-Titan Krios II at Diamond open access Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily Jiwei Liu, Matteo Tassinari, Diorge P. De Souza, Souvik Naskar, Jeffrey K. Noel, Olga Bohuszewicz, Martin Buck, Tom A. Williams, Buzz Baum, Harry H. Low
Cell, 184 Jul 2021 DOI: 10.1016/j.cell.2021.05.041 Molecular view of a key protein could help make cancer cells more vulnerable to treatments Xiaodong Zhang, Luke Yates
Jul 2021 Diamond Annual Review Highlight Krios I-Titan Krios I at Diamond Krios III-Titan Krios III at Diamond
Mapping antibody recognition of SARS-CoV-2 spike protein Jingshan Ren, David I. Stuart
Jul 2021 Diamond Annual Review Highlight I03-Macromolecular Crystallography Krios I-Titan Krios I at Diamond
Visualising a bacterial multi-substrate recruitment machine in action Amit Meir, Gabriel Waksman
Jul 2021 Diamond Annual Review Highlight Krios IV-Titan Krios IV at Diamond
Visualising a membrane receptor complex to enhance drug development Christopher G. Tate
Jul 2021 Diamond Annual Review Highlight Krios I-Titan Krios I at Diamond
Cryo-EM visualises dynamic molecular machines Oscar Llorca
Jul 2021 Diamond Annual Review Highlight Krios I-Titan Krios I at Diamond
Probing the biogenesis pathway and dynamics of thylakoid membranes Tuomas Huokko, Tao Ni, Gregory F. Dykes, Deborah M. Simpson, Philip Brownridge, Fabian D. Conradi, Robert J. Beynon, Peter J. Nixon, Conrad W. Mullineaux, Peijun Zhang, Lu-Ning Liu
Nature Communications, 12 June 2021 DOI: 10.1038/s41467-021-23680-1 Gating and modulation of a hetero-octameric AMPA glutamate receptor Danyang Zhang, Jake F. Watson, Peter M. Matthews, Ondrej Cais, Ingo H. Greger
Nature, 62 June 2021 DOI: 10.1038/s41586-021-03613-0 3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme Melisa Lazaro, Roberto Melero, Charlotte Huet, Jorge Lopez-Alonso, Sandra Delgado, Alexandra Dodu, Eduardo M. Bruch, Luciano A. Abriata, Pedro M. Alzari, Mikel Valle, María-Natalia Lisa
Communications Biology, 4 June 2021 DOI: 10.1038/s42003-021-02222-x A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit Andreas Schedlbauer, Idoia Iturrioz, Borja Ochoa-Lizarralde, Tammo Diercks, Jorge Pedro Lopez-Alonso, José Luis Lavin, Tatsuya Kaminishi, Retina Çapuni, Neha Dhimole, Elisa De Astigarraga, David Gil-Carton, Paola Fucini, Sean R. Connell
Science Advances, 7 June 2021 DOI: 10.1126/sciadv.abf7547 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access Structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii Daniel Mann, Junping Fan, Kamolrat Somboon, Daniel P. Farrell, Andrew Muenks, Svetomir B. Tzokov, Frank Dimaio, Syma Khalid, Samuel I. Miller, Julien R. C. Bergeron
Communications Biology, 4 June 2021 DOI: 10.1038/s42003-021-02318-4 Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab1 Antonio Galindo, Vicente J. Planelles-Herrero, Gianluca Degliesposti, Sean Munro
The Embo Journal, 40 June 2021 DOI: 10.15252/embj.2020107608 Single particle cryo-electron microscopy: From sample to structure Joshua B. R. White, Daniel P. Maskell, Andrew Howe, Martin Harrow, Daniel K. Clare, C. Alistair Siebert, Emma L. Hesketh, Rebecca F. Thompson
Journal Of Visualized Experiments, May 2021 DOI: 10.3791/62415 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond Talos-Talos Arctica at Diamond open access Cryo-EM studies of Phosphatidylinositol-3-kinase related kinase (PIKK) structures from yeast: Transcription-associated protein 1 (Tra1) and Mitosis-entry checkpoint 1 (Mec1), and their role as conserved genomic regulators Luis Miguel Diaz-Santin
May 2021 Thesis Krios I-Titan Krios I at Diamond open access
Structural basis of TRAPPIII‐mediated Rab1 activation Aaron M. N. Joiner, Ben P. Phillips, Kumar Yugandhar, Ethan J Sanford, Marcus B Smolka, Haiyuan Yu, Elizabeth A. Miller, J Christopher Fromme
The Embo Journal, 74 May 2021 DOI: 10.15252/embj.2020107607 Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine Yasunori Watanabe, Luiza Mendonca, Elizabeth R. Allen, Andrew Howe, Mercede Lee, Joel D. Allen, Himanshi Chawla, David Pulido, Francesca Donnellan, Hannah Davies, Marta Ulaszewska, Sandra Belij-Rammerstorfer, Susan Morris, Anna-Sophia Krebs, Wanwisa Dejnirattisai, Juthathip Mongkolsapaya, Piyada Supasa, Gavin R. Screaton, Catherine M. Green, Teresa Lambe, Peijun Zhang, Sarah C. Gilbert, Max Crispin
Acs Central Science, Apr 2021 DOI: 10.1021/acscentsci.1c00080 CryoET structures of immature HIV Gag reveal six-helix bundle Luiza Mendonca, Dapeng Sun, Jiying Ning, Jiwei Liu, Abhay Kotecha, Mateusz Olek, Thomas Frosio, Xiaofeng Fu, Benjamin A. Himes, Alex B. Kleinpeter, Eric O. Freed, Jing Zhou, Christopher Aiken, Peijun Zhang
Communications Biology, 4 Apr 2021 DOI: 10.1038/s42003-021-01999-1 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Krios III-Titan Krios III at Diamond open access Simultaneous binding of guidance cues NET1 and RGM blocks extracellular NEO1 signaling Ross A. Robinson, Samuel C. Griffiths, Lieke L. Van De Haar, Tomas Malinauskas, Eljo Y. Van Battum, Pavol Zelina, Rebekka A. Schwab, Dimple Karia, Lina Malinauskaite, Sara Brignani, Marleen H. Van Den Munkhof, Özge Düdükcü, Anna A. De Ruiter, Dianne M.a. Van Den Heuvel, Benjamin Bishop, Jonathan Elegheert, A. Radu Aricescu, R. Jeroen Pasterkamp, Christian Siebold
Cell, 74 Mar 2021 DOI: 10.1016/j.cell.2021.02.045 Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography Krios IV-Titan Krios IV at Diamond open access Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation Stanislau Yatskevich, Jessie S. Kroonen, Claudio Alfieri, Thomas Tischer, Anna C. Howes, Linda Clijsters, Jing Yang, Ziguo Zhang, Kaige Yan, Alfred C. O. Vertegaal, David Barford
Cell Reports, 34 Mar 2021 DOI: 10.1016/j.celrep.2021.108929 Structural basis for conformational equilibrium of the catalytic spliceosome Max E. Wilkinson, Sebastian M. Fica, Wojciech P. Galej, Kiyoshi Nagai
Molecular Cell, 74 Mar 2021 DOI: 10.1016/j.molcel.2021.02.021 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access Alternative architecture of the E. coli chemosensory array Alister Burt, C. Keith Cassidy, Phillip J. Stansfeld, Irina Gutsche
Biomolecules, 11 Mar 2021 DOI: 10.3390/biom11040495 Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607 Yang Shi, Alexey G. Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L. Newell, Ruben Vidal, Holly J. Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors H. W. Scheres, Michel Goedert
Acta Neuropathologica, 66 Mar 2021 DOI: 10.1007/s00401-021-02294-3 Malaria pigment crystals: The achilles′ heel of the malaria parasite Sergey Kapishnikov, Ernst Hempelmann, Michael Elbaum, Jens Als‐nielsen, Leslie Leiserowitz
Chemmedchem, 4 Mar 2021 DOI: 10.1002/cmdc.202000895 The antigenic anatomy of SARS-CoV-2 receptor binding domain Wanwisa Dejnirattisai, Daming Zhou, Helen M. Ginn, Helen M. E. Duyvesteyn, Piyada Supasa, James Brett Case, Yuguang Zhao, Thomas Walter, Alexander J. Mentzer, Chang Liu, Beibei Wang, Guido C. Paesen, Jose Slon-Campos, César López-Camacho, Natasha M. Kafai, Adam L. Bailey, Rita E. Chen, Baoling Ying, Craig Thompson, Jai Bolton, Alex Fyfe, Sunetra Gupta, Tiong Kit Tan, Javier Gilbert-Jaramillo, William James, Michael Knight, Miles W. Carroll, Donal Skelly, Christina Dold, Yanchun Peng, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Paul Klenerman, Nigel Temperton, David R. Hall, Mark A. Williams, Neil G. Paterson, Felicity Bertram, C. Alistair Siebert, Daniel K. Clare, Andrew Howe, Julika Radecke, Yun Song, Alain R. Townsend, Kuan-Ying A. Huang, Elizabeth E. Fry, Juthathip Mongkolsapaya, Michael S. Diamond, Jingshan Ren, David I. Stuart, Gavin R. Screaton
Cell, Feb 2021 DOI: 10.1016/j.cell.2021.02.032 Journal Paper I03-Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access Interface mobility between monomers in dimeric bovine ATP synthase participates in the ultrastructure of inner mitochondrial membranes Tobias E. Spikes, Martin G. Montgomery, John E. Walker
Proceedings Of The National Academy Of Sciences, 118 Feb 2021 DOI: 10.1073/pnas.2021012118 Journal Paper Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond open access Mechanism of membrane-tethered mitochondrial protein synthesis Yuzuru Itoh, Juni Andrell, Austin Choi, Uwe Richter, Priyanka Maiti, Robert B. Best, Antoni Barrientos, Brendan J. Battersby, Alexey Amunts
Science, 371 Feb 2021 DOI: 10.1126/science.abe0763 Shulin packages axonemal outer dynein arms for ciliary targeting Girish R. Mali, Ferdos Abid Ali, Clinton K. Lau, Farida Begum, Jérôme Boulanger, Jonathan D. Howe, Zhuo A. Chen, Juri Rappsilber, Mark Skehel, Andrew Carter
Science, 371 Feb 2021 DOI: 10.1126/science.abe0526 DNA origami signposts for identifying proteins on cell membranes by electron cryotomography Emma Silvester, Benjamin Vollmer, Vojtech Prazak, Daven Vasishtan, Emily A. Machala, Catheryne Whittle, Susan Black, Jonathan Bath, Andrew J. Turberfield, Kay Grunewald, Lindsay A. Baker
Cell, 184 Feb 2021 DOI: 10.1016/j.cell.2021.01.033 Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins Max Renner, Wanwisa Dejnirattisai, Loic Carrique, Itziar Serna Martin, Dimple Karia, Serban L. Ilca, Shu F. Ho, Abhay Kotecha, Jeremy R. Keown, Juthathip Mongkolsapaya, Gavin R. Screaton, Jonathan M. Grimes
Nature Communications, 12 Feb 2021 DOI: 10.1038/s41467-021-21505-9 SAP domain forms a flexible part of DNA aperture in Ku70/80 Ales Hnizda, Petr Tesina, Than-Binh Nguyen, Zdeněk Kukačka, Lukas Kater, Amanda K. Chaplin, Roland Beckmann, David B. Ascher, Petr Novák, Tom L. Blundell
The Febs Journal, Feb 2021 DOI: 10.1111/febs.15732 Architecture of the Tuberous Sclerosis Protein Complex Kailash Ramlaul, Wencheng Fu, Hua Li, Natalia De Martin Garrido, Lin He, Manjari Trivedi, Wei Cui, Christopher H. S. Aylett, Geng Wu
Journal Of Molecular Biology, 433 Jan 2021 DOI: 10.1016/j.jmb.2020.166743 Structures of Rhodopseudomonas palustris RC-LH1 complexes with open or closed quinone channels David J. K. Swainsbury, Pu Qian, Philip J. Jackson, Kaitlyn M. Faries, Dariusz M. Niedzwiedzki, Elizabeth C. Martin, David A. Farmer, Lorna A. Malone, Rebecca F. Thompson, Neil A. Ranson, Daniel P. Canniffe, Mark J. Dickman, Dewey Holten, Christine Kirmaier, Andrew Hitchcock, C. Neil Hunter
Science Advances, 7 Jan 2021 DOI: 10.1126/sciadv.abe2631 Structure of the class D GPCR Ste2 dimer coupled to two G proteins Vaithish Velazhahan, Ning Ma, Gáspár Pándy-Szekeres, Albert J. Kooistra, Yang Lee, David E. Gloriam, Nagarajan Vaidehi, Christopher G. Tate
Nature, 589 Jan 2021 DOI: 10.1038/s41586-020-2994-1