The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM Javier O. Cifuente, Natalia Comino, Cecilia D'Angelo, Alberto Marina, David Gil-Carton, David Albesa-Jove, Marcelo Guerin
Current Research In Structural Biology, 2 Nov 2020 DOI: 10.1016/j.crstbi.2020.04.005 Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase Elias A. Tannous, Luke A. Yates, Xiaodong Zhang, Peter M. Burgers
Nature Structural & Molecular Biology, 149 Nov 2020 DOI: 10.1038/s41594-020-00522-0 Journal Paper Krios I-Titan Krios I at Diamond Krios III-Titan Krios III at Diamond High-light versus low-light: Effects on paired photosystem II supercomplex structural rearrangement in pea plants Alessandro Grinzato, Pascal Albanese, Roberto Marotta, Paolo Swuec, Guido Saracco, Martino Bolognesi, Giuseppe Zanotti, Cristina Pagliano
International Journal Of Molecular Sciences, 21 Nov 2020 DOI: 10.3390/ijms21228643 Structure of Nora virus at 2.7 Å resolution and implications for receptor binding, capsid stability and taxonomy Pasi Laurinmaki, Shabih Shakeel, Jens-Ola Ekström, Pezhman Mohammadi, Dan Hultmark, Sarah J. Butcher
Scientific Reports, 10 Nov 2020 DOI: 10.1038/s41598-020-76613-1 Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM Andrés López-Perrote, Nele Hug, Ana González-Corpas, Carlos F. Rodríguez, Marina Serna, Carmen Garcia-Martin, Jasminka Boskovic, Rafael Fernandez-Leiro, Javier F Caceres, Oscar Llorca
Elife, 9 Nov 2020 DOI: 10.7554/eLife.63042 Host ANP32A mediates the assembly of the influenza virus replicase Loic Carrique, Haitian Fan, Alexander P. Walker, Jeremy R. Keown, Jane Sharps, Ecco Staller, Wendy S. Barclay, Ervin Fodor, Jonathan M. Grimes
Nature, 4 Nov 2020 DOI: 10.1038/s41586-020-2927-z Structural basis for tuning activity and membrane specificity of bacterial cytolysins Nita R. Shah, Tomas B. Voisin, Edward S. Parsons, Courtney M. Boyd, Bart W. Hoogenboom, Doryen Bubeck
Nature Communications, 11 Nov 2020 DOI: 10.1038/s41467-020-19482-6 Journal Paper Krios I-Titan Krios I at Diamond Krios III-Titan Krios III at Diamond Krios V-Titan Krios V at Diamond open access A human protein is essential for spreading Flu Diamond Light Source
Nov 2020 Science Highlight Krios IV-Titan Krios IV at Diamond
Structure of inhibitor-bound mammalian complex I Hannah R. Bridges, Justin G. Fedor, James N. Blaza, Andrea Di Luca, Alexander Jussupow, Owen D. Jarman, John J. Wright, Ahmed-Noor A. Agip, Ana P. Gamiz-Hernandez, Maxie M. Roessler, Ville R. I. Kaila, Judy Hirst
Nature Communications, 11 Oct 2020 DOI: 10.1038/s41467-020-18950-3 The structure of a triple complex of plant photosystem I with ferredoxin and plastocyanin Ido Caspy, Anna Borovikova-Sheinker, Daniel Klaiman, Yoel Shkolnisky, Nathan Nelson
Nature Plants, 80 Oct 2020 DOI: 10.1038/s41477-020-00779-9 Assembly intermediates of orthoreovirus captured in the cell Geoff Sutton, Dapeng Sun, Xiaofeng Fu, Abhay Kotecha, Corey W. Hecksel, Daniel K. Clare, Peijun Zhang, David I. Stuart, Mark Boyce
Nature Communications, 11 Sept 2020 DOI: 10.1038/s41467-020-18243-9 Structure of the dimeric ATP synthase from bovine mitochondria Tobias E. Spikes, Martin Montgomery, John E. Walker
Proceedings Of The National Academy Of Sciences, 117 Sept 2020 DOI: 10.1073/pnas.2013998117 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond open access The prefusion structure of herpes simplex virus glycoprotein B B. Vollmer, V. Prazak, D. Vasishtan, E. E. Jefferys, A. Hernandez-Duran, M. Vallbracht, B. G. Klupp, T. C. Mettenleiter, M. Backovic, F. A. Rey, M. Topf, K. Grunewald
Science Advances, 6 Sept 2020 DOI: 10.1126/sciadv.abc1726 Structure of a human 48 S translational initiation complex Jailson Brito Querido, Masaaki Sokabe, Sebastian Kraatz, Yuliya Gordiyenko, J. Mark Skehel, Christopher S. Fraser, Venki Ramakrishnan
Science, 369 Sept 2020 DOI: 10.1126/science.aba4904 Structures of α-synuclein filaments from multiple system atrophy Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G. Murzin, Bernardino Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Shigeo Murayama, Mari Yoshida, Masato Hasegawa, Sjors H. W. Scheres, Michel Goedert
Nature, 585 Sept 2020 DOI: 10.1038/s41586-020-2317-6 Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A Tao Ni, Samuel Gerard, Gongpu Zhao, Kyle Dent, Jiying Ning, Jing Zhou, Jiong Shi, Jordan Anderson-Daniels, Wen Li, Sooin Jang, Alan N. Engelman, Christopher Aiken, Peijun Zhang
Nature Structural & Molecular Biology, 5 Aug 2020 DOI: 10.1038/s41594-020-0467-8 Journal Paper Krios I-Titan Krios I at Diamond Krios IV-Titan Krios IV at Diamond Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation Daniel Grba, Judy Hirst
Nature Structural & Molecular Biology, 82 Aug 2020 DOI: 10.1038/s41594-020-0473-x A workflow for protein structure determination from thin crystal lamella by micro-electron diffraction Emma V. Beale, David G. Waterman, Corey Hecksel, Jason Van Rooyen, James B. Gilchrist, James M. Parkhurst, Felix De Haas, Bart Buijsse, Gwyndaf Evans, Peijun Zhang
Frontiers In Molecular Biosciences, 7 Aug 2020 DOI: 10.3389/fmolb.2020.00179 Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis Rafael Nunez-Ramirez, Juanjo Huesa, Yolanda Bel, Juan Ferré, Patricia Casino, Ernesto Arias-Palomo
Nature Communications, 11 Aug 2020 DOI: 10.1038/s41467-020-17758-5 Journal Paper Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond open access Dual role of the active site ‘lid’ regions of protochlorophyllide oxidoreductase in photocatalysis and plant development Shaowei Zhang, Alan R. F. Godwin, Aoife Taylor, Samantha J. O. Hardman, Thomas A. Jowitt, Linus O. Johannissen, Sam Hay, Clair Baldock, Derren J. Heyes, Nigel S. Scrutton
The Febs Journal, 288 Aug 2020 DOI: 10.1111/febs.15542 Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 Jiangdong Huo, Audrey Le Bas, Reinis R. Ruza, Helen M. E. Duyvesteyn, Halina Mikolajek, Tomas Malinauskas, Tiong Kit Tan, Pramila Rijal, Maud Dumoux, Philip N. Ward, Jingshan Ren, Daming Zhou, Peter J. Harrison, Miriam Weckener, Daniel K. Clare, Vinod K. Vogirala, Julika Radecke, Lucile Moynie, Yuguang Zhao, Javier Gilbert-Jaramillo, Michael L. Knight, Julia A. Tree, Karen R. Buttigieg, Naomi Coombes, Michael J. Elmore, Miles W. Carroll, Loic Carrique, Pranav N. M. Shah, William James, Alain R. Townsend, David I. Stuart, Raymond J. Owens, James H. Naismith
Nature Structural & Molecular Biology, 21 Jul 2020 DOI: 10.1038/s41594-020-0469-6 Journal Paper I03-Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state Leifu Chang, Jing Yang, Chang Hwa Jo, Andreas Boland, Ziguo Zhang, Stephen H. Mclaughlin, Afnan Abu-Thuraia, Ryan C. Killoran, Matthew J. Smith, Jean-Francois Côté, David Barford
Nature Communications, 11 Jul 2020 DOI: 10.1038/s41467-020-17271-9 Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient Daming Zhou, Helen M. E. Duyvesteyn, Cheng-Pin Chen, Chung-Guei Huang, Ting-Hua Chen, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Che Ma, Jiandong Huo, Loic Carrique, Tomas Malinauskas, Reinis R. Ruza, Pranav Shah, Tiong Kit Tan, Pramila Rijal, Robert F. Donat, Kerry Godwin, Karen R. Buttigieg, Julia A. Tree, Julika Radecke, Neil Paterson, Piyada Supasa, Juthathip Mongkolsapaya, Gavin R. Screaton, Miles W. Carroll, Javier Gilbert-Jaramillo, Michael L. Knight, William James, Raymond J. Owens, James H. Naismith, Alain R. Townsend, Elizabeth E. Fry, Yuguang Zhao, Jingshan Ren, David I. Stuart, Kuan-Ying A. Huang
Nature Structural & Molecular Biology, 20 Jul 2020 DOI: 10.1038/s41594-020-0480-y Journal Paper I03-Macromolecular Crystallography Krios I-Titan Krios I at Diamond Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism Byung-Gil Lee, Fabian Merkel, Matteo Allegretti, Markus Hassler, Christopher Cawood, Léa Lecomte, Francis J. O'Reilly, Ludwig R. Sinn, Pilar Gutierrez-Escribano, Marc Kschonsak, Sol Bravo, Takanori Nakane, Juri Rappsilber, Luis Aragon, Martin Beck, Jan Lowe, Christian H. Haering
Nature Structural & Molecular Biology, 53 Jul 2020 DOI: 10.1038/s41594-020-0457-x The polyglutamine expansion at the n-terminal of Huntingtin protein modulates the dynamic configuration and phosphorylation of the c-terminal HEAT domain Taeyang Jung, Baehyun Shin, Giorgio Tamo, Hyeongju Kim, Ravi Vijayvargia, Alexander Leitner, Maria J. Marcaida, Juan Astorga-Wells, Roy Jung, Ruedi Aebersold, Matteo Dal Peraro, Hans Hebert, Ihn Sik Seong, Ji-Joon Song
Structure, Jul 2020 DOI: 10.1016/j.str.2020.06.008 Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA Martin L. Rennie, Kimon Lemonidis, Connor Arkinson, Viduth K Chaugule, Mairi Clarke, James Streetley, Laura Spagnolo, Helen Walden
Embo Reports, 21 Jul 2020 DOI: 10.15252/embr.202050133 FtsK in motion reveals its mechanism for double-stranded DNA translocation Nicolas L. Jean, Trevor J. Rutherford, Jan Lowe
Proceedings Of The National Academy Of Sciences, 6 June 2020 DOI: 10.1073/pnas.2001324117 Neutralisation of SARS-CoV-2 by destruction of the prefusion Spike Jiandong Huo, Yuguang Zhao, Jingshan Ren, Daming Zhou, Helen M. E. Duyvesteyn, Helen M. Ginn, Loic Carrique, Tomas Malinauskas, Reinis R. Ruza, Pranav N. M. Shah, Tiong Kit Tan, Pramila Rijal, Naomi Coombes, Kevin R. Bewley, Julia A. Tree, Julika Radecke, Neil Paterson, Piyasa Supasa, Juthathip Mongkolsapaya, Gavin R. Screaton, Miles Carroll, Alain Townsend, Elizabeth E. Fry, Raymond J. Owens, David I. Stuart
Cell Host & Microbe, June 2020 DOI: 10.1016/j.chom.2020.06.010 Journal Paper I03-Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila Amit Meir, Kevin Mace, Natalya Lukoyanova, David Chetrit, Manuela K. Hospenthal, Adam Redzej, Craig Roy, Gabriel Waksman
Nature Communications, 11 June 2020 DOI: 10.1038/s41467-020-16681-z Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor Yang Lee, Tony Warne, Rony Nehmé, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Madhu Chaturvedi, Patricia C. Edwards, Javier Garcia-Nafria, Andrew G. W. Leslie, Arun K. Shukla, Christopher G. Tate
Nature, 159 June 2020 DOI: 10.1038/s41586-020-2419-1 Interactions of a bacterial RND transporter with a transmembrane small protein in a lipid environment Dijun Du, Arthur Neuberger, Mona Wu Orr, Catherine E. Newman, Pin-Chia Hsu, Firdaus Samsudin, Andrzej Szewczak-Harris, Leana M. Ramos, Mekdes Debela, Syma Khalid, Gisela Storz, Ben Luisi
Structure, 28 June 2020 DOI: 10.1016/j.str.2020.03.013 Cryo-EM structure of the fork protection complex bound to CMG at a replication fork Domagoj Baretic, Michael Jenkyn-Bedford, Valentina Aria, Giuseppe Cannone, Mark Skehel, Joseph T. P. Yeeles
Molecular Cell, 78 June 2020 DOI: 10.1016/j.molcel.2020.04.012 The cryo-EM structure of the bacterial flagellum cap complex suggests a molecular mechanism for filament elongation Natalie S. Al-Otaibi, Aidan J. Taylor, Daniel P. Farrell, Svetomir B. Tzokov, Frank Dimaio, David J. Kelly, Julien R. C. Bergeron
Nature Communications, 11 June 2020 DOI: 10.1038/s41467-020-16981-4 The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer M. Arif M. Jamali, Chai C. Gopalasingam, Rachel M. Johnson, Takehiko Tosha, Kazumasa Muramoto, Stephen P. Muench, Svetlana V. Antonyuk, Yoshitsugu Shiro, Samar Hasnain
Iucrj, 7 May 2020 DOI: 10.1107/S2052252520003656 Cryo-electron microscopy reveals two distinct type IV pili assembled by the same bacterium Alexander Neuhaus, Muniyandi Selvaraj, Ralf Salzer, Julian D. Langer, Kerstin Kruse, Lennart Kirchner, Kelly Sanders, Bertram Daum, Beate Averhoff, Vicki A. M. Gold
Nature Communications, 11 May 2020 DOI: 10.1038/s41467-020-15650-w The architecture of EMC reveals a path for membrane protein insertion John P. O'Donnell, Ben P. Phillips, Yuichi Yagita, Szymon Juszkiewicz, Armin Wagner, Duccio Malinverni, Robert J Keenan, Elizabeth Miller, Ramanujan S. Hegde
Elife, 9 May 2020 DOI: 10.7554/eLife.57887 Journal Paper I03-Macromolecular Crystallography I23-Long wavelength MX Krios III-Titan Krios III at Diamond open access An assessment of the use of Hepatitis B Virus core protein virus-like particles to display heterologous antigens from Neisseria meningitidis Sebastian Aston-Deaville, Emil Carlsson, Muhammad Saleem, Angela Thistlethwaite, Hannah Chan, Sunil Maharjan, Alessandra Facchetti, Ian M. Feavers, C. Alistair Siebert, Richard F. Collins, Alan Roseman, Jeremy P. Derrick
Vaccine, 38 Apr 2020 DOI: 10.1016/j.vaccine.2020.03.001 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access A steric “ball-and-chain” mechanism for pH-mediated regulation of gap junction channels Ali K. Khan, Maciej Jagielnicki, William E. Mcintire, Michael D. Purdy, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Mark Yeager
Cell Reports, 31 Apr 2020 DOI: 10.1016/j.celrep.2020.03.046 Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes Andrew Hartley, Brigitte Meunier, Nikos Pinotsis, Amandine Marechal
Proceedings Of The National Academy Of Sciences, 117 Apr 2020 DOI: 10.1073/pnas.1920612117 Journal Paper Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond The helical arrangement of nitrilase enzymes determines their substrate size Jeremy D. Woodward, Angela M. Kirykowicz, Andani E. Mulelu, Markus Piotrowski, Trevor D. Sewell
The Faseb Journal, 34 Apr 2020 DOI: 10.1096/fasebj.2020.34.s1.04283 The structure of human thyroglobulin Francesca Coscia, Ajda Taler-Verčič, Veronica T. Chang, Ludwig Sinn, Francis J. O'Reilly, Thierry Izore, Miha Renko, Imre Berger, Juri Rappsilber, Dušan Turk, Jan Lowe
Nature, 37 Feb 2020 DOI: 10.1038/s41586-020-1995-4 Morphological development of Pleurochyrsis carterae coccoliths examined by cryo-electron tomography J. M. Walker, B. Marzec, N. Ozaki, D. Clare, F. Nudelman
Journal Of Structural Biology, Feb 2020 DOI: 10.1016/j.jsb.2020.107476 Mechanism of crosstalk between the LSD1 demethylase and HDAC1 deacetylase in the CoREST complex Yun Song, Lisbeth Dagil, Louise Fairall, Naomi Robertson, Mingxuan Wu, T. J. Ragan, Christos G. Savva, Almutasem Saleh, Nobuhiro Morone, Micha B. A. Kunze, Andrew G. Jamieson, Philip A. Cole, D. Flemming Hansen, John W. R. Schwabe
Cell Reports, 30 Feb 2020 DOI: 10.1016/j.celrep.2020.01.091 Journal Paper B21-High Throughput SAXS Krios I-Titan Krios I at Diamond open access Complete structure of the chemosensory array core signalling unit in an E. coli minicell strain Alister Burt, C. Keith Cassidy, Peter Ames, Maria Bacia-Verloop, Megghane Baulard, Karine Huard, Zaida Luthey-Schulten, Ambroise Desfosses, Phillip J. Stansfeld, William Margolin, John S. Parkinson, Irina Gutsche
Nature Communications, 11 Feb 2020 DOI: 10.1038/s41467-020-14350-9 FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair Pablo Alcon, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Ketan J. Patel, Lori Passmore
Nature Structural & Molecular Biology, 493 Feb 2020 DOI: 10.1038/s41594-020-0380-1 Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation Pierre-Damien Coureux, Christine Lazennec-Schurdevin, Sophie Bourcier, Yves Mechulam, Emmanuelle Schmitt
Communications Biology, 3 Feb 2020 DOI: 10.1038/s42003-020-0780-0 Structural basis of transcription inhibition by the DNA mimic protein Ocr of bacteriophage T7 Fuzhou Ye, Ioly Kotta-Loizou, Milija Jovanovic, Xiaojiao Liu, David T. F. Dryden, Martin Buck, Xiaodong Zhang
Elife, 9 Feb 2020 DOI: 10.7554/eLife.52125 A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair Kaiying Cheng, Martin Wilkinson, Yuriy Chaban, Dale B. Wigley
Nature Structural & Molecular Biology, 27 Jan 2020 DOI: 10.1038/s41594-019-0355-2 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond open access