Cryo-EM structures of the human INO80 chromatin-remodeling complex Ricardo Aramayo, Oliver Willhoft, Rafael Ayala, Rohan Bythell-Douglas, Dale B. Wigley, Xiaodong Zhang
Nature Structural & Molecular Biology, 25 Dec 2017 DOI: 10.1038/s41594-017-0003-7 Architecture of eukaryotic mRNA 3′-end processing machinery Ana Casanal, Ananthanarayanan Kumar, Chris H. Hill, Ashley D. Easter, Paul Emsley, Gianluca Degliesposti, Yuliya Gordiyenko, Balaji Santhanam, Jana Wolf, Katrin Wiederhold, Gillian L. Dornan, Mark Skehel, Carol V. Robinson, Lori A. Passmore
Science, 546 Oct 2017 DOI: 10.1126/science.aao6535 Tall tails of mRNA Diamond Light Source
Oct 2017 Science Highlight Krios I-Titan Krios I at Diamond
Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine Johanna Marsian, Helen Fox, Mohammad W. Bahar, Abhay Kotecha, Elizabeth E. Fry, David I. Stuart, Andrew J. Macadam, David J. Rowlands, George P. Lomonossoff
Nature Communications, 8 Aug 2017 DOI: 10.1038/s41467-017-00090-w Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase Celia Deville, Marta Carroni, Kamila B. Franke, Maya Topf, Bernd Bukau, Axel Mogk, Helen R. Saibil
Science Advances, 3 Aug 2017 DOI: 10.1126/sciadv.1701726 Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution Luis Miguel Diaz-Santin, Natalya Lukoyanova, Emir Aciyan, Alan Cheung
Elife, 6 Aug 2017 DOI: 10.7554/eLife.28384 Growing a better polio vaccine Diamond Light Source
Aug 2017 Science Highlight Krios I-Titan Krios I at Diamond
The structure of the R2TP complex defines a platform for recruiting diverse client proteins to the HSP90 molecular chaperone system Angel Rivera-Calzada, Mohinder Pal, Hugo Muñoz-Hernández, Juan R. Luque-Ortega, David Gil-Carton, Gianluca Degliesposti, J. Mark Skehel, Chrisostomos Prodromou, Laurence H. Pearl, Oscar Llorca
Structure, 25 Jul 2017 DOI: 10.1016/j.str.2017.05.016 Checking the checkpoint Diamond Light Source
Jul 2017 Science Highlight I04-Macromolecular Crystallography Krios I-Titan Krios I at Diamond
Electron Bio-Imaging Centre (eBIC): the UK national research facility for biological electron microscopy Daniel K. Clare, C. Alistair Siebert, Corey Hecksel, Christoph Hagen, Valerie Mordhorst, Michael Grange, Alun W. Ashton, Martin A. Walsh, Kay Grunewald, Helen R. Saibil, Dave I. Stuart, Peijun Zhang
Acta Crystallographica Section D Structural Biology, 73 June 2017 DOI: 10.1107/S2059798317007756 Structures of RNA polymerase closed and intermediate complexes reveal mechanisms of DNA opening and transcription initiation Robert Glyde, Fuzhou Ye, Vidya Chandran Darbari, Nan Zhang, Martin Buck, Xiaodong Zhang
Molecular Cell, June 2017 DOI: 10.1016/j.molcel.2017.05.010 Cryo-EM reveals how human cytoplasmic dynein is auto-inhibited and activated Kai Zhang, Helen E. Foster, Arnaud Rondelet, Samuel E. Lacey, Nadia Bahi-Buisson, Alexander W. Bird, Andrew P. Carter
Cell, June 2017 DOI: 10.1016/j.cell.2017.05.025 The structure of the tetanus toxin reveals pH‐mediated domain dynamics Geoffrey Masuyer, Julian Conrad, Pal Stenmark
Embo Reports, June 2017 DOI: 10.15252/embr.201744198 Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) Krios I-Titan Krios I at Diamond Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint Pietro Roversi, Lucia Marti, Alessandro T. Caputo, Dominic S. Alonzi, Johan C. Hill, Kyle C. Dent, Abhinav Kumar, Mikail D. Levasseur, Andrea Lia, Thomas Waksman, Souradeep Basu, Yentli Soto Albrecht, Kristin Qian, James Patrick Mcivor, Colette B. Lipp, Dritan Siliqi, Snezana Vasilijevic, Shabaz Mohammed, Petra Lukacik, Martin A. Walsh, Angelo Santino, Nicole Zitzmann
Proceedings Of The National Academy Of Sciences Pnas, June 2017 DOI: 10.1073/pnas.1703682114 Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) Krios I-Titan Krios I at Diamond HBV RNA pre-genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly Nikesh Patel, Simon J. White, Rebecca F. Thompson, Richard Bingham, Eva U. Weiß, Daniel P. Maskell, Adam Zlotnick, Eric C. Dykeman, Roman Tuma, Reidun Twarock, Neil A. Ranson, Peter G. Stockley
Nature Microbiology, 2 June 2017 DOI: 10.1038/nmicrobiol.2017.98 RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket Jorge Pedro López-Alonso, Tatsuya Kaminishi, Takeshi Kikuchi, Yuya Hirata, Idoia Iturrioz, Neha Dhimole, Andreas Schedlbauer, Yoichi Hase, Simon Goto, Daisuke Kurita, Akira Muto, Shu Zhou, Chieko Naoe, Deryck J. Mills, David Gil-Carton, Chie Takemoto, Hyouta Himeno, Paola Fucini, Sean R. Connell
Nucleic Acids Research, 45 June 2017 DOI: 10.1093/nar/gkx324 Ribosome rearrangements at the onset of translational bypassing Xabier Agirrezabala, Ekaterina Samatova, Mariia Klimova, Miguel Zamora, David Gil-Carton, Marina V. Rodnina, Mikel Valle
Science Advances, 3 June 2017 DOI: 10.1126/sciadv.1700147 Structure of the MacAB–TolC ABC-type tripartite multidrug efflux pump Anthony Fitzpatrick, Salomé Llabrés, Arthur Neuberger, James N. Blaza, Xiao-Chen Bai, Ui Okada, Satoshi Murakami, Hendrik W. Van Veen, Ulrich Zachariae, Sjors H. W. Scheres, Ben F. Luisi, Dijun Du
Nature Microbiology, 2 May 2017 DOI: 10.1038/nmicrobiol.2017.70 Cryo-EM structure of a relaxase reveals the molecular basis of DNA unwinding during bacterial conjugation Aravindan Ilangovan, Christopher W. M. Kay, Sandro Roier, Hassane El Mkami, Enrico Salvadori, Ellen L. Zechner, Giulia Zanetti, Gabriel Waksman
Cell, Apr 2017 DOI: 10.1016/j.cell.2017.04.010 Full-length, oligomeric structure of Wzz determined by cryoelectron microscopy reveals insights into membrane-bound states Richard Collins, Vasileios Kargas, Brad R. Clarke, C. Alistair Siebert, Daniel K. Clare, Peter J. Bond, Chris Whitfield, Robert C. Ford
Structure, Apr 2017 DOI: 10.1016/j.str.2017.03.017 Solving the separase–securin complex Diamond Light Source
Apr 2017 Science Highlight Krios I-Titan Krios I at Diamond
Cryo-EM structure of a metazoan separase–securin complex at near-atomic resolution Andreas Boland, Thomas G. Martin, Ziguo Zhang, Jing Yang, Xiao-Chen Bai, Leifu Chang, Sjors H W Scheres, David Barford
Nature Structural & Molecular Biology, 104 Mar 2017 DOI: 10.1038/nsmb.3386 An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump Zhao Wang, Guizhen Fan, Corey F Hryc, James N. Blaza, Irina I. Serysheva, Michael F Schmid, Wah Chiu, Ben Luisi, Dijun Du
Elife, 6 Mar 2017 DOI: 10.7554/eLife.24905 Journal Paper I24-Microfocus Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access Structure of a spliceosome remodelled for exon ligation Sebastian M. Fica, Chris Oubridge, Wojciech P. Galej, Max E. Wilkinson, Xiao-Chen Bai, Andrew J. Newman, Kiyoshi Nagai
Nature, Jan 2017 DOI: 10.1038/nature21078 The FA core complex contains a homo-dimeric catalytic module for the symmetric mono-ubiquitination of FANCI-FANCD2 Paolo Swuec, Ludovic Renault, Aaron Borg, Fenil Shah, Vincent J. Murphy, Sylvie Van Twest, Ambrosius P. Snijders, Andrew J. Deans, Alessandro Costa
Cell Reports, 18 Jan 2017 DOI: 10.1016/j.celrep.2016.11.013