These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
Structural mechanism underlying variations in DNA binding by the androgen receptor Xiao Yin Lee, Wout Van Eynde, Christine Helsen, Hanne Willems, Kaat Peperstraete, Sofie De Block, Arnout Voet, Frank Claessens
The Journal Of Steroid Biochemistry And Molecular Biology, 241 Jul 2024 DOI: 10.1016/j.jsbmb.2024.106499 Journal Paper I24-Microfocus Macromolecular Crystallography open access Retromer‐mediated recruitment of the WASH complex involves discrete interactions between VPS35 , VPS29, and FAM21 Miguel Romano-Moreno, Elsa N. Astorga-Simon, Adriana L. Rojas, Aitor Hierro
Protein Science, 33 May 2024 DOI: 10.1002/pro.4980 Journal Paper I24-Microfocus Macromolecular Crystallography open access 70 years in the making: a historical virus sample reveals a novel protein structure Diamond Light Source
May 2024 Science Highlight I24-Microfocus Macromolecular Crystallography VMXm-Versatile Macromolecular Crystallography microfocus
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response Yahui Yan, Maithili Shetty, Heather P. Harding, Ginto George, Alisa Zyryanova, Katherine Labbé, Amirhossein Mafi, Qi Hao, Carmela Sidrauski, David Ron
Proceedings Of The National Academy Of Sciences, 121 Apr 2024 DOI: 10.1073/pnas.2320013121 Journal Paper I24-Microfocus Macromolecular Crystallography open access An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin Jake A. Hill, Yvonne Nyathi, Sam Horrell, David Von Stetten, Danny Axford, Robin L. Owen, Godfrey S. Beddard, Arwen R. Pearson, Helen M. Ginn, Briony Yorke
Communications Chemistry, 7 Apr 2024 DOI: 10.1038/s42004-024-01163-w Journal Paper I24-Microfocus Macromolecular Crystallography open access Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing Weiwei Peng, Koen Cap Giesbers, Marta Šiborová, J. Wouter Beugelink, Matti F. Pronker, Douwe Schulte, John Hilkens, Bert J. C. Janssen, Karin Strijbis, Joost Snijder
Life Science Alliance, 7 Mar 2024 DOI: 10.26508/lsa.202302366 Journal Paper I24-Microfocus Macromolecular Crystallography open access Revisiting strategies and their combinatorial effect for introducing peroxygenase activity in CYP102A1 (P450BM3) Jasmin C. Aschenbrenner, Ana C. Ebrecht, Martha S. Smit, Diederik J. Opperman
Molecular Catalysis, 557 Mar 2024 DOI: 10.1016/j.mcat.2024.113953 Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Structure and function of Semaphorin-5A glycosaminoglycan interactions Gergely N. Nagy, Xiao-Feng Zhao, Richard Karlsson, Karen Wang, Ramona Duman, Karl Harlos, Kamel El Omari, Armin Wagner, Henrik Clausen, Rebecca L. Miller, Roman J. Giger, E. Yvonne Jones
Nature Communications, 15 Mar 2024 DOI: 10.1038/s41467-024-46725-7 Journal Paper I03-Macromolecular Crystallography I23-Long wavelength MX I24-Microfocus Macromolecular Crystallography open access Proteins containing photosynthetic reaction centre domains modulate FtsZ-based archaeal cell division Phillip Nußbaum, Danguole Kureisaite-Ciziene, Dom Bellini, Chris Van Der Does, Marko Kojic, Najwa Taib, Anna Yeates, Maxime Tourte, Simonetta Gribaldo, Martin Loose, Jan Lowe, Sonja-Verena Albers
Nature Microbiology, 9 Mar 2024 DOI: 10.1038/s41564-024-01600-5 A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus Rachel Bolton, Moritz M. Machelett, Jack Stubbs, Danny Axford, Nicolas Caramello, Lucrezia Catapano, Martin Maly, Matthew J. Rodrigues, Charlotte Cordery, Graham J. Tizzard, Fraser Macmillan, Sylvain Engilberge, David Von Stetten, Takehiko Tosha, Hiroshi Sugimoto, Jonathan A. R. Worrall, Jeremy S. Webb, Mike Zubkov, Simon Coles, Eric Mathieu, Roberto A. Steiner, Garib Murshudov, Tobias E. Schrader, Allen M. Orville, Antoine Royant, Gwyndaf Evans, Michael A. Hough, Robin L. Owen, Ivo Tews
Proceedings Of The National Academy Of Sciences, 121 Mar 2024 DOI: 10.1073/pnas.2308478121 7.10 MAG. a novel host monoacylglyceride for in meso (lipid cubic phase) crystallization of membrane proteins Pawel Krawinski, Luke Smithers, Leendert Van Dalsen, Coilin Boland, Nikita Ostrovitsa, Javier Pérez, Martin Caffrey
Crystal Growth & Design, 63 Mar 2024 DOI: 10.1021/acs.cgd.4c00087 Journal Paper I24-Microfocus Macromolecular Crystallography open access Structural dissection of two redox proteins from the shipworm symbiont Teredinibacter turnerae Badri S. Rajagopal, Nick Yates, Jake Smith, Alessandro Paradisi, Catherine Tétard-Jones, William G. T. Willats, Susan Marcus, J. Paul Knox, Mohd Firdaus-Raih, Bernard Henrissat, Gideon J. Davies, Paul H. Walton, Alison Parkin, Glyn R. Hemsworth
Iucrj, 11 Mar 2024 DOI: 10.1107/S2052252524001386 Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2 William J. Bradshaw, Emma C. Kennedy, Tiago Moreira, Luke A. Smith, Rod Chalk, Vittorio L. Katis, Justin L. P. Benesch, Paul E. Brennan, Emma J. Murphy, Opher Gileadi
Structure, 44 Feb 2024 DOI: 10.1016/j.str.2024.01.005 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Rational design of a cyclohexanone dehydrogenase for enhanced α, β-desaturation and substrate specificity Warispreet Singh, Nicola Brown, Hannah V. Mccue, Sophie R. Marriott, Richard C. Wilson, Justin Perry, Johan P. Turkenburg, Kshatresh D. Dubey, Stephen H. Prior, Andrew J. Carnell, Edward J. Taylor, Gary W. Black
Chemical Science, Feb 2024 DOI: 10.1039/D3SC04009G Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access Human 2´-deoxynucleoside 5´-phosphate N-Hydrolase 1: the catalytic roles of Tyr24 and Asp80 Anna E. Carberry, Suneeta Devi, David J. Harrison, Rafael G. Da Silva
Chembiochem, Feb 2024 DOI: 10.1002/cbic.202400047 Functional and structural asymmetry suggest a unifying principle for catalysis in membrane-bound pyrophosphatases Jannik Strauss, Craig Wilkinson, Keni Vidilaseris, Orquidea M. De Castro Ribeiro, Jianing Liu, James Hillier, Maximilian Wichert, Anssi M. Malinen, Bernadette Gehl, Lars J. C. Jeuken, Arwen R. Pearson, Adrian Goldman
Embo Reports, 215 Jan 2024 DOI: 10.1038/s44319-023-00037-x Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4 Lucy Barnsby-Greer, Peter D. Mabbitt, Marc-Andre Dery, Daniel R. Squair, Nicola T. Wood, Frederic Lamoliatte, Sven M. Lange, Satpal Virdee
Nature Structural & Molecular Biology, 116 Jan 2024 DOI: 10.1038/s41594-023-01192-4 Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module Nicholas A. Arce, Zoe Markham-Lee, Qian Liang, Shabir Najmudin, Emily R. Legan, Gabrielle Dean, Ally J. Su, Moriah S. Wilson, Robert F. Sidonio, Pete Lollar, Jonas Emsley, Renhao Li
Blood Journal, Jan 2024 DOI: 10.1182/blood.2023022038 The crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion Manickam Gurusaran, Benedikte S. Erlandsen, Owen R. Davies
Communications Biology, 7 Jan 2024 DOI: 10.1038/s42003-024-05794-6 Journal Paper B21-High Throughput SAXS I24-Microfocus Macromolecular Crystallography open access Using BpyAla to generate copper artificial metalloenzymes: a catalytic and structural study E. Klemencic, R. C. Brewster, H. S. Ali, J. M. Richardson, A. G. Jarvis
Catalysis Science & Technology, 24 Jan 2024 DOI: 10.1039/D3CY01648J Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access